Modelling and systems investigations of mRNA translation and directed cell migration

Modelling and systems investigations of mRNA translation and directed cell migration

Abstract

In the past few years, there has been great interest in the quantitative investigation of various biological processes, loosely termed "systems biology". In this talk we discuss modelling and systems investigations aimed at understanding two intracellular processes. The first process is mRNA translation, which is a basic and crucial genetic process involved in synthesis of proteins in cells. Here we focus on the role of feedback regulation mechanisms involved in mRNA translation in yeast. This involves modelling and systems analysis of this process, in collaboration with experimentalists. The second process in directed cell migration of eukaryotic cells -- the migration of cells in response to gradients of chemical concentrations and other factors. This process plays critical roles in many important processes such as wound healing, tumour metastasis, immune system response and development.Here we will discuss some modelling results as well as systems analysis aimed at understanding the signal processing which connects the cells' sensing of external chemical concentrations to its migratory response. Overall the focus is on the modelling of reaction and transport processes involved in these processes as well as systems analysis. If time permits, some broader insights and systems biology challenges suggested by these investigations will be discussed.